賀紅武、彭浩、譚效松編著的《環境友好型烴基
膦酸酯類除草劑(英文版)(精)》以植物丙酮酸脫氫酶
繫（PDHc）為靶標的烴基膦酸酯類除草劑的設計、研
究與應用為主線，繫統介紹了PDHc抑制劑研究的新進
展、以烴基膦酸酯為基本骨架設計環境友好型除草劑
的分子設計理念，研究思路，從基礎研究到田間應用
的研究過程和結果。重點介紹了幾類烴基膦酸酯的分
子設計、合成、表征、除草活性研究以及相關方法學
, 包括烴基膦酸酯類光學異構體的不對稱合成及生物
活性研究。其內容涉及分子設計，先導化合物的發現
、先導結構修飾，化學合成，結構表征，生物篩選、
構效關繫分析、分子對接研究、結構優化、活性化合
物生物學特性等。本書還介紹了烴基膦酸酯作為植物
PDHc抑制劑的生物化學作用機理研究，高活性化合物
(包括氯酰草膦和HWS)作為除草劑應用的生物學特性,
田間藥效、殘留、毒性、對環境生態的影響等多個環
節的研究與評價結果。
本書可供從事化學，有機合成，有機磷化學，化
學生物學，分子生物學，農藥化學，新農藥創制研究
等領域研究者、科技人員參考，也可供高等院校農藥
、植保、農學等專業高年級本科生、研究生及教師使
用。

1 Overview
1.1 Introduction
1.1.1 Mode of Action of Herbicide
1.1.2 Herbicide Resistance
1.1.3 New Opportunity for Novel Herbicides
1.1.4 Basic Methodology for Discovery of Hit/Lead Compounds
1.2 Pyruvate Dehydrogenase Complex (PDHc)
1.2.1 Function of PDHc
1.2.2 Distribution of PDHc
1.2.3 Plant PDHc E1 as Site of Action of Herbicide
1.3 Progress in the Research of PDHc Inhibitors
1.3.1 OP Compounds as Inhibitors of E. coli PDHc
1.3.2 OP Compounds as Inhibitors of Plant PDHc
1.3.3 Enzyme-Selective Inhibition of OP Compounds
1.4 Design of Novel PDHc E1 Inhibitors as Herbicides
1.4.1 Selecting Plant PDHc E1 as Target of New Herbicide
1.4.2 PDHc E1 Inhibitor Acylphosphonate as Hit Compound
1.4.3 Finding Lead Structure IA
1.4.4 Optimization Strategy
1.5 Book Chapter Organization
References
2 Alkylphosphonates
2.1 (Alkyl or Substituted Phenyl)Methylphosphonates IA-IF
2.1.1 Introduction
2.1.2 Synthesis of O,O-Dialkyl 1-Hydroxyalkylphosphonates M2
2.1.3 Synthesis of Substituted Phenoxyacetic Acids M4 and Substituted Phenoxyacetyl Chlorides M5
2.1.4 Synthesis of IA-IF
2.1.5 Spectroscopic Analysis of IA-IF
2.1.6 Crystal Structure Analysis of IC-7
2.1.7 Herbicidal Activity of IA-IF
2.1.8 Structure-Herbicidal Activity Relationships
2.1.9 Herbicidal Activity of IC-22
2.1.10 Summary
2.2 Heterocyclylmethylphosphonates IG-IJ
2.2.1 Introduction
2.2.2 Synthesis of IG-IJ
2.2.3 Spectroscopic Analysis of IG-IJ
2.2.4 Crystal Structure Analysis of IH-18 and IG-21
2.2.5 Herbicidal Activity of IG-IJ
2.2.6 Structure-Herbicidal Activity Relationships
2.2.7 Herbicidal Activity of IG-21
2.2.8 Summary
2.3 (1-Phenyl- 1,2,4-Triazol-3-yloxyacetoxy) Alkylphosphonates IK
2.3.1 Introduction
2.3.2 Synthesis of IK
2.3.3 Spectroscopic Analysis of IK
2.3.4 Herbicidal Activity of IK
2.3.5 Summary
References
3 Salts of Alkylphosphonates
3.1 Alkali Metal Salts of O-Alkyl Alkylphosphonic Acids ⅡA-ⅡE
3.1.1 Introduction
3.1.2 Synthesis of ⅡA-ⅡE
3.1.3 Spectroscopic Analysis of ⅡA-ⅡE
3.1.4 Crystal Structure Analysis of liB-20
3.1.5 Herbicidal Activity of ⅡA-ⅡE
3.1.6 Summary
3.2 Alkali Metal Salts of Alkylphosphonic Acids ⅡF,IIG and IIH
3.2.1 Introduction
3.2.2 Synthesis of ⅡF, ⅡG and ⅡH
3.2.3 Spectroscopic Analysis of ⅡF, ⅡG and ⅡH
3.2.4 Herbicidal Activity of ⅡF, ⅡG and ⅡH
3.2.5 Summary
……
4 Alkylphosphinates
5 Cyclic Phosphonates and Caged Bicyclic Phosphates
6 Optically Active Alkylphosphonates
7 Biochemical Mechanism of Alkylphosphonates
8 Evaluation and Application of Clacyfos and HWS
9 General Methodology