費伯所著的《有機化學中的生物轉化（第6版）
》主要包括5個部分：引言和背景知識部分對生物催
化劑進行了深入淺出的精練概括和評述；生物催化劑
的應用從多個方面對近幾十年來生物催化劑在有機合
成中的應用進行了繫統全面的總結；專用技術部分重
點概括了生物催化劑在有機合成中的應用、生物催化
劑的固定化及酶的修飾和人工模擬；技術現狀與展望
部分對生物催化劑的現狀和未來的發展做了詳細介紹
；附錄部分則從實用的角度為讀者提供了非常有價值
的信息資料。

1 Introduction and Background lnformation
1.1 Introduction
1.2 Common Prejudices Against Enzymes
1.3 Advantages and Disadvantages of Biocatalysts
1.3.1 Advantages of Biocatalysts
1.3.2 Disadvantages of Biocatalysts
1.3.3 Isolated Enzymes vs. Whole Cell Systems
1.4 Enzyme Properties and Nomenclature
1.4.1 Structural Biology in a Nutshell
1.4.2 Mechanistic Aspects of Enzyme Catalysis
1.4.3 Classification and Nomenclature
1.4.4 Coenzymes
1.4.5 Enzyme Sources
References
2 Biocatalytic Applications
2.1 Hydrolytic Reactions
2.1.1 Mechanistic and Kinetic Aspects
2.1.2 Hydrolysis ofthe Amide Bond
2.1.3 EsterHydrolysis
2.1.4 Hydrolysis and Formation ofPhosphate Esters
2.1.5 Hydrolysis ofEpoxides
2.1.6 Hydrolysis of Nitriles
2.2 Reduction Reactions
2.2.1 Recycling ofCofactors
2.2.2 Reduction of Aldehydes and Ketones Using IsolatedEnzymes
2.2.3 Reduction of Aldehydes and Ketones Using Whole Cells
2.2.4 Reduction of C-C-Bonds
2.3 Oxidation Reactions
2.3.1 Oxidation of Alcohols and Aldehydes
2.3.2 Oxygenation Reactions
2.3.3 Peroxidation Reactions
2.4 Formation of Carbon-Carbon Bonds
2.4.1 Aldol Reactions
2.4.2 Thiamine-Dependent Acyloin and Benzoin Reactions
2.4.3 Michael-Type Additions
2.5 Addition and Elimination Reactions
2.5.1 Cyanohydrin Formation
2.5.2 Addition of Water
2.5.3 Addition of Ammonia
2.6 Transfer Reactions
2.6.1 Glycosyl Transfer Reactions
2.6.2 Amino Transfer Reactions
2.7 Halogenation and Dehalogenation Reactions
2.7.1 Halogenation
2.7.2 Dehalogenation
References
3 SpeciaI Techniques
3.1 Enzymes in Organic Solvents
3.1.1 Ester Synthesis
3.1.2 Lactone Synthesis
3.1.3 Amide Synthesis
3.1.4 Peptide Synthesis
3.1.5 Peracid Synthesis
3.1.6 Redox Reactions
3.1.7 Medium Engineering
3.2 Immobilization
3.3 Artificial and Modified Enzymes
3.3.1 Artificial Enzyme Mimics
3.3.2 Modified Enzymes
3.3.3 Catalytic Antibodies
References
4 State of the Art and Outlook
References
5 Appendix
5.1 Basic Rules for Handling Biocatalysts
5.2 Abbreviations
5.3 Suppliers of Enzymes
5.4 Commonly Used Enzyme Preparations
5.5 MajorCulture Collections
5.6 Pathogenic Bacteria and Fungi
Index